In prep for the ERA biopsy, we looked into whether this procedure would create an issue with regard to halacha.
Because of the nature of the procedure being time sensitive, it is by design scheduled during tahor days. Fertility treatment is already a game of "Red-Light, Green-Light, 1-2-3" with regard to niddah. Beside for the hormones messing with mind and body affecting interest, there's also the tangible issue of hormone-inducing spotting every so often. Taharat hamishpacha is a challenging mitzvah even in the best of times, and even more so when tahor weeks become shorter and shorter.
So I asked whether the procedure itself would render me niddah. Uterine bleeding will almost always result from an endometrial biopsy. Since this bleeding is caused by injury, the opinion of the posek on yoatzot.org, Ravi Henkin, is that it does not render a woman niddah. In addition, for all procedures that enter the uterus, the size of the instrument that enters is also relevant. As long as the catheter used for the endometrial biopsy is smaller than 19mm, the instruments entry into the uterus would not itself make one niddah.
I was told that the bleeding may go on for about a week, and for that time can be attributed to the procedure, but by that point I will have stopped all meds and will be expecting an actual period.
For anyone interested, this website is a great source of information. I love the Yoatzot.org website and appreciate that they are available to answer these questions.
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